Special Lecture
The IL-23 to IL-17 cascade inflammation-related cancers
K. Wang1, M. Karin2
- Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, Moores Cancer Center, UCSD School of Medicine, La Jolla, CA, USA.
- Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, Moores Cancer Center, UCSD School of Medicine, La Jolla, CA, USA. karinoffice@ucsd.edu
CER8931
2015 Vol.33, N°4 ,Suppl.92
PI 0087, PF 0090
Special Lecture
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PMID: 26457610 [PubMed]
Received: 03/09/2015
Accepted : 03/09/2015
In Press: 12/10/2015
Published: 14/10/2015
Abstract
Two inflammatory cytokines, IL-23 and IL-17A, produced by myeloid cells and different lymphocyte subsets, were found to play important pathogenic functions in several inflammation-related cancers. In colorectal cancer, elevated expression of IL-23, IL-23 receptor and IL-17A has been linked to adverse prognostic outcome and rapid progression to metastatic disease. In mouse models of colorectal tumourigenesis genetic or pharmacological inhibition of these cytokines attenuates tumour development and malignant progression. Collectively, such findings suggest that IL-23 and/or IL-17A inhibitors should be evaluated for their therapeutic and preventative potential in human cancers, especially in colorectal cancer.
