Special Lecture
Environments of hematopoiesis and B-lymphopoiesis in foetal liver
K. Kajikhina1, M. Tsuneto2, F. Melchers3
- Max Planck Fellow Research Group on “Lymphocyte Development”, Max Planck Institute for Infection Biology, Berlin, Germany.
- Max Planck Fellow Research Group on “Lymphocyte Development”, Max Planck Institute for Infection Biology, Berlin, Germany; and Department of Stem Cell and Developmental Biology, Mie University Graduate School of Medicine, Tsu, Japan.
- Max Planck Fellow Research Group on “Lymphocyte Development”, Max Planck Institute for Infection Biology, Berlin, Germany. melchers@mpiib-berlin.mpg.de
CER8932
2015 Vol.33, N°4 ,Suppl.92
PI 0091, PF 0093
Special Lecture
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PMID: 26457725 [PubMed]
Received: 03/09/2015
Accepted : 03/09/2015
In Press: 12/10/2015
Published: 14/10/2015
Abstract
In human and murine embryonic development, haematopoiesis and B-lymphopoiesis show stepwise differentiation from pluripotent haematopoietic stem cells and multipotent progenitors, over lineage-restricted lymphoid and myeloid progenitors to B-lineage committed precursors and finally differentiated pro/preB cells. This wave of differentiation is spatially and temporally organised by the surrounding, mostly non-haematopoietic cell niches. We review here recent developments and our current contributions on the research on blood cell development.
