impact factor, citescore
logo
In press
In Press
Recent issue
Recent issue
Recent Supplement
Recent supplement
archives
Archives
articles free
Free to view
Search
Search
 

Full Papers

 

Comparison on radiographic progression for 5 years between juvenile onset ankylosing spondylitis and adult onset ankylosing spondylitis: an observational study of the Korean SpondyloArthropathy Registry (OSKAR) data

1, 2, 3, 4, 5, 6

 

  1. Department of Rheumatology, Research Institute of Medical Sciences, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea.
  2. Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea.
  3. Department of Orthopaedics, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea.
  4. Department of Radiology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea.
  5. Department of Radiology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea.
  6. Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea. thkim@hanyang.ac.kr

CER9066
2016 Vol.34, N°4
PI 0668, PF 0672
Full Papers

Free to view
(click on article PDF icon to read the article)

PMID: 27051061 [PubMed]

Received: 23/10/2015
Accepted : 25/01/2016
In Press: 06/04/2016
Published: 14/07/2016

Abstract

OBJECTIVES:
To evaluate differences in radiographic progression between adult-onset ankylosing spondylitis (AoAS) and juvenile-onset ankylosing spondylitis (JoAS).
METHODS:
A total of 533 patients (418 patients with AoAS and 115 patients with JoAS) from the Observation Study of Korean spondyloArthropathy Registry (OSKAR) cohort were enrolled. All baseline OSKAR data were analysed in relation to disease onset and radiographic progression was analysed between the groups over 5 years. The modified Stoke AS Spinal Score (mSASSS) were used by two experienced radiologists. Clinical data were collected to investigate the associations between clinical factors and radiographic progression. Radiographic scores were compared using analysis of covariance model after adjusting for confounding factors.
RESULTS:
Inter-reader reliability for baseline mSASSS was very good. Inter-reader reliability for the changes in the mSASSS was also good. A significant difference in baseline mSASSS (mean ± SD) unit was detected between the AoAS and JoAS groups (18.1±17.4 vs. 14.3±13.8, p=0.015). We assessed the change in mSASSS to confirm whether age at onset affected radiographic progression. A simple comparison revealed a significant difference between changes on the mSASSS (mean ± SEM) between the JoAS and AoAS groups (1.75±0.71 vs. 3.77±0.56, p<0.001). After adjusting for multiple comparisons, change on the mSASSS remained lower in patients with JoAS than those with AoAS (0.28±1.33 vs. 4.08±0.62, p=0.016).
CONCLUSIONS:
Patients with JoAS had slower radiographic spinal damage progression over 5 years than those with AoAS.

Rheumatology Article