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Endostatin is higher and associated with pulmonary involvement in primary Sjögren’s syndrome

1, 2, 3, 4, 5, 6, 7, 8

 

  1. Department of Rheumatology, Oslo University Hospital Rikshospitalet, Oslo, Norway. opalm@ous-hf.no
  2. Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet; and Institute of Clinical Medicine, University of Oslo, Norway.
  3. Department of Rheumatology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
  4. Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet; and Institute of Clinical Medicine, University of Oslo, Norway.
  5. Department of Rheumatology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
  6. Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet; Institute of Clinical Medicine, University of Oslo; and Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital, Rikshospitalet, Norway.
  7. Department of Radiology and Nuclear Medicine, Oslo University Hospital Rikshospitalet, Norway.
  8. Department of Rheumatology, Oslo University Hospital Rikshospitalet; and Institute of Clinical Medicine, University of Oslo, Norway.

CER9152
2016 Vol.34, N°4
PI 0690, PF 0693
Brief Papers

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PMID: 27214260 [PubMed]

Received: 28/11/2015
Accepted : 08/02/2016
In Press: 19/05/2016
Published: 14/07/2016

Abstract

OBJECTIVES:
To investigate serum levels of endostatin in a well characterised cohort of patients with primary Sjögren’s syndrome (pSS) and healthy controls (HC) and assess associations between these mediators and clinical parameters.
METHODS:
All patients (n=144) were recruited from the Norwegian systemic connective tissue disease and vasculitis registry (NOSVAR) and fulfilled American-European classification criteria for pSS. Pulmonary involvement was based on clinical symptoms and abnormal findings on high-resolution computed tomography of the lungs. The controls were 100 healthy blood donors. Serum levels of endostatin was determined by enzyme immunoassay.
RESULTS:
We found higher mean levels of serum endostatin in patients with pSS compared with the controls (p<0.001). The patients with interstitial lung disease (ILD) had higher levels compared with those without pulmonary involvement.
CONCLUSIONS:
Our results indicate that endostatin is increased in patients with pSS and particularly in those with ILD.

Rheumatology Article