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Venous thrombosis and relapses in patients with Behçet’s disease. Descriptive analysis from Spanish network of Behçet’s disease (REGEB cohort)


1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15

 

  1. Department of Internal Medicine, Hospital Universitari Mútua Terrassa, Barcelona, Spain.
  2. Department of Internal Medicine, Hospital Vall d'Hebron, Barcelona, Spain.
  3. Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo, Spain.
  4. Unit of Connective Tissue Diseases, Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla, Spain.
  5. Autoimmune Systemic Diseases Unit, Department of Internal Medicine, Hospital Clínico San Cecilio, Granada, Spain.
  6. Autoimmune Diseases Unit, Department of Internal Medicine, Hospital de Cruces, Galdakao, Bilbao, Spain.
  7. Department of Internal Medicine, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
  8. Department of Internal Medicine, Hospital Vall d'Hebron, Barcelona, Spain.
  9. Department of Internal Medicine, Hospital de Cabueñes, Gijón, Spain.
  10. Department of Internal Medicine, Hospital de Mollet, Barcelona, Spain.
  11. Department of Internal Medicine, Hospital Universitario Ramón y Cajal, Madrid, Spain.
  12. Department of Internal Medicine, Hospital Universitario Clínico de Zaragoza, Spain.
  13. Department of Internal Medicine, Hospital Universitario Clínico de Zaragoza, Spain.
  14. Department of Internal Medicine, Hospital de la Vega Baja, Orihuela, Alicante, Spain.
  15. Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Spain. gespino@clinic.cat

on behalf of REGEB investigators, Autoimmune Diseases Study Group (GEAS)

CER11034
2018 Vol.36, N°6 ,Suppl.115
PI 0040, PF 0044
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PMID: 29745871 [PubMed]

Received: 08/12/2017
Accepted : 13/03/2018
In Press: 03/05/2018
Published: 13/12/2018

Abstract

OBJECTIVES:
To describe the characteristics of patients with Behçet’s disease (BD) who presented with venous thrombosis. In addition, we identified the factors associated with this venous involvement and those related with recurrent venous thrombosis.
METHODS:
Up to January 2015, 544 BD patients from 20 Spanish hospitals had been included in the REGEB (REGistro de la Enfermedad de Behçet as Spanish nomenclature). We selected those patients who presented venous thrombosis. Descriptive analysis was performed and factors related with venous thrombosis were identified.
RESULTS:
Overall, 99 (18.2%) BD patients had vascular thrombosis, 91 (16.7%) of them (16.7%) involving venous vessels and 18 (19.7%) suffered from venous thrombotic relapse. Lower limbs were the most common location of deep venous thrombosis present in up to 60% of patients. In 12 (13.2%) patients, venous thrombosis affected two vascular territories simultaneously and in 6 (6.6%) the venous and arterial involvement coincided in time. Overall, at the diagnosis of venous thrombosis, 97.6% of patients presented concomitantly other clinical symptoms attributable to BD. In logistic regression multivariate analysis factors associated to venous thrombosis were male sex (Odds ratio [OR] 4.3, 95% confidence interval [CI] 2.5-7.7), erythema nodosum (OR 2.4, 95%CI 1.4-4.1), fever (OR 2.0, 95%CI 1.1-3.8), and central nervous system (CNS) involvement (OR 2.5, 95%CI 1.3-4.8). Considering relapses, CNS involvement was an independent risk factor according logistic regression. However, Cox multivariate analysis did not confirm this finding.
CONCLUSIONS:
We identified factors related with venous involvement in patients included in the REGEB cohort.

Rheumatology Article