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Oral ulcer activity assessment with the composite index according to different treatment modalities in Behçet’s syndrome: a multicentre study

1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29

 

  1. Marmara University, Faculty of Health Sciences, Istanbul, Turkey.
  2. Gulhane Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, University of Health Sciences, Ankara, Turkey. ukaracayli@gmail.com
  3. Department of Statistics, Mimar Sinan Fine Arts University, Istanbul, Turkey.
  4. Marmara University, Medical School, Division of Rheumatology, Istanbul, Turkey.
  5. Ege University, Medical School, Division of Rheumatology, Izmir, Turkey.
  6. Hacettepe University, Medical School, Division of Rheumatology, Ankara, Turkey.
  7. Hacettepe University, Medical School, Division of Rheumatology, Ankara, Turkey.
  8. Akdeniz University, Medical School, Dermatology Department, Antalya, Turkey.
  9. Gulhane Medical Faculty, Gulhane Education and Research Hospital, Division of Rheumatology, Gulhane, Turkey.
  10. Kocaeli University, Medical School, Division of Rheumatology, Kocaeli, Turkey.
  11. Cukurova University, Medical School, Division of Rheumatology, Adana, Turkey.
  12. Şanlıurfa Mehmet Akif Inan Education and Research Hospital, Sanliurfa, Turkey.
  13. Istanbul Bakırköy Dr.Sadi Konuk Education and Research Hospital, Rheumatology Clinic, Istanbul, Turkey.
  14. Cumhuriyet University, Medical School, Division of Rheumatology, Sivas, Turkey.
  15. Cukurova University, Medical School, Division of Rheumatology, Adana, Turkey.
  16. Kocaeli University, Medical School, Division of Rheumatology, Kocaeli, Turkey.
  17. Gulhane Medical Faculty, Gulhane Education and Research Hospital, Division of Rheumatology, Gulhane, Turkey.
  18. Gulhane Medical Faculty, Gulhane Education and Research Hospital, Division of Rheumatology, Gulhane, Turkey.
  19. Hacettepe University, Medical School, Division of Rheumatology, Ankara, Turkey.
  20. Erciyes University, Medical School, Division of Rheumatology, Kayseri, Turkey.
  21. Eskisehir, Osmangazi University, Medical School, Division of Rheumatology, Eskisehir, Turkey.
  22. Eskisehir, Osmangazi University, Medical School, Division of Rheumatology, Eskisehir, Turkey.
  23. Hacettepe University, Medical School, Division of Rheumatology, Ankara, Turkey.
  24. Ege University, Medical School, Division of Rheumatology, Izmir, Turkey.
  25. Ege University, Medical School, Division of Rheumatology, Izmir, Turkey.
  26. Marmara University, Medical School, Division of Rheumatology, Istanbul, Turkey.
  27. Marmara University, Medical School, Division of Rheumatology, Istanbul, Turkey.
  28. Marmara University, Medical School, Dermatology Department, Istanbul, Turkey.
  29. Marmara University, Medical School, Division of Rheumatology, Istanbul, Turkey.

CER12393
2019 Vol.37, N°6 ,Suppl.121
PI 0098, PF 0104
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PMID: 31856935 [PubMed]

Received: 04/05/2019
Accepted : 18/09/2019
In Press: 09/12/2019
Published: 09/12/2019

Abstract

OBJECTIVES:
The aim of this multicentre study was to understand patients’ needs and to evaluate the oral ulcer activity with the Composite Index (CI), according to different treatment modalities in Behçet’s syndrome (BS).
METHODS:
BS patients (n=834) from 12 centres participated in this cross-sectional study. Oral ulcer activity (active vs. inactive) and the CI (0: inactive vs. 1-10 points: active) were evaluated during the previous month. The effects of treatment protocols [non-immunosuppressive: non-IS vs. immunosuppressive: (ISs)], severity (mild vs. severe), disease duration (<5 years vs. ≥5 years) and smoking pattern (non-smoker vs. current smoker) were analysed for oral ulcer activity.
RESULTS:
Oral ulcer activity was observed in 65.1% of the group (n=543). In both genders, the activity was higher in mild disease course with non-IS treatment group compared to severe course with ISs (p<0.05). As a resistant group, patients with mild disease course whose mucocutaneous symptoms were unresponsive to non-IS medications were treated with ISs in a limited period and achieved the highest CI scores in females. Oral ulcer activity and poor CI score were associated with disease duration less than 5 years compared to others in male patients (p<0.05).
CONCLUSIONS:
Oral ulcer activity pattern is affected by both the combination of disease course, treatment protocols and disease duration. CI scores reflected the oral clinical activity and CI might be a candidate scale to evaluate the efficacy of treatments during the follow-up of oral ulcer activity in BS.

Rheumatology Article