impact factor
logo
 

Diagnosis

 

Nailfold capillaroscopy in Sjögren’s syndrome: a systematic literature review and standardised interpretation


1, 2, 3, 4, 5, 6, 7, 8, 9

 

  1. Department of Rheumatology, Ghent University Hospital, and Department of Internal Medicine, Ghent University, Belgium. karin.melsens@ugent.be
  2. Department of Rheumatology, Ghent University Hospital, Belgium, and Rheumatology Unit, Department of Internal Medicine, University of Perugia, Italy.
  3. Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Italy.
  4. Department of Rheumatology, Ghent University Hospital, and Department of Internal Medicine, Ghent University, Belgium.
  5. Rheumatology Unit, Department of Internal Medicine, University of Perugia, Italy.
  6. Department of Rheumatology, Ghent University Hospital, and Department of Internal Medicine, Ghent University, Belgium.
  7. Department of Rheumatology, Ghent University Hospital, Belgium.
  8. Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Italy.
  9. Department of Rheumatology, Ghent University Hospital; Department of Internal Medicine, Ghent University, and Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Centre (IRC), Ghent, Belgium.

CER13590
2020 Vol.38, N°4 ,Suppl.126
PI 0150, PF 0157
Diagnosis

Free to view
(click on article PDF icon to read the article)

PMID: 33025880 [PubMed]

Received: 20/05/2020
Accepted : 13/07/2020
In Press: 21/09/2020
Published: 23/10/2020

Abstract

OBJECTIVES:
To identify the role of nailfold capillaroscopy (NC) in Sjögren’s syndrome (SS).
METHODS:
The literature was systematically reviewed in three databases. All published original studies which assess patients with SS by NC were revised. A quality assessment was applied to all studies based on population description, presence of a control group, presence of instrumental specifications and/or standardly applied NC methodology, presence of clear descriptions of capillaroscopic characteristics and based on the used statistical analysis. The capillaroscopic findings per study were described in a EULAR consented standardised way. Significant associations of capillaroscopic characteristics in SS patients with clinical and laboratory variables were summarised.
RESULTS:
The search resulted in 869 hits. Based on title and abstract screening 29 original studies were identified and of these, 14 full texts described an assessment by NC in SS. Seven studies were retained after performing a critical quality assessment. One study compared NC in SS with healthy controls and attested a lower capillary density in SS. Concerning clinical associations, capillary density was associated with Raynaud’s phenomenon in two studies and with interstitial lung disease or systemic manifestations in one study each. No association between serologic features (anti-nuclear antibodies, anti-SSA, anti-SSB and anti-RF) and NC characteristics were found.
CONCLUSIONS:
A small number of studies have investigated the role of NC in SS. More studies, including prospective follow up studies with standard NC evaluation in SS are needed.

Rheumatology Article

Rheumatology Addendum