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Osteopontin: another piece in the systemic lupus erythematosus immunopathology puzzle

1, 2, 3, 4, 5, 6

 

  1. Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Departamento de Biología Molecular y Genómica, Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético (IIRSME), Guadalajara, and UDG-CA-703, Inmunología y Reumatología, Guadalajara, Mexico. bethymar@hotmail.com
  2. Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Departamento de Biología Molecular y Genómica, Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético (IIRSME), Guadalajara, and Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Departamento de Clínicas Médicas, Guadalajara, Mexico.
  3. Universidad de Guadalajara, Centro Universitario de Tonalá, Departamento de Ciencias Biomédicas, División de Ciencias de la Salud, Tonalá, Jalisco, Mexico.
  4. Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Departamento de Biología Molecular y Genómica, Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético (IIRSME), Guadalajara, Mexico; and Department of Cardiothoracic and Vascular Surgey, Örebro University Hospital, Region Örebro County, Sweden.
  5. Universidad de Guadalajara, Centro Universitario de los Altos, Jalisco, México.
  6. Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Departamento de Biología Molecular y Genómica, Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético (IIRSME), Guadalajara; UDG-CA-703, Inmunología y Reumatología, Guadalajara, and Hospital Civil de Guadalajara Dr Juan I. Menchaca, División de Medicina Interna, Servicio de Reumatología, CONACyT PNPC, Guadalajara, Mexico.

CER14447
2022 Vol.40, N°1
PI 0173, PF 0182
Reviews

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PMID: 34128791 [PubMed]

Received: 21/01/2021
Accepted : 13/04/2021
In Press: 05/05/2021
Published: 28/01/2022

Abstract

Osteopontin (OPN) is a phosphoglycoprotein involved in bone remodelling, wound healing, cell adhesion, tissue remodelling, and immune response that is distributed widely in normal adult tissues. OPN biological activity is regulated by thrombin and matrix metalloproteinases (MMPs) cleavage, where the full-length (OPN-FL) protein and the cleaved OPN-N are associated with autoimmune diseases such as systemic lupus erythematosus (SLE). OPN overexpression has been associated with a predisposition to SLE and bad prognosis since OPN could mediate a sustained polyclonal B cell activation that besides to intracellular OPN (iOPN) form, promote the T follicular helper (TFH) cells and enhance anti-nuclear antibody production. Currently, the role of OPN in lupus nephritis (LN) has been reported and extensively studied; however, no data are available about the potential mechanism of OPN in neuropsychiatric SLE (NPSLE). In this review, we highlighted the contribution of OPN and iOPN in LN and NPSLE immunopathology.

DOI: https://doi.org/10.55563/clinexprheumatol/x2g7rp

Rheumatology Article