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IL-1β, IL-10 and TNF-α polymorphisms may affect systemic lupus erythematosus risk and phenotype


1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11

 

  1. Department of Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.
  2. Department of Computer Science and Statistics, Poznan University of Medical Sciences, Poznan, Poland.
  3. Department of Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.
  4. Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznan, Poland.
  5. Department of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.
  6. Department of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.
  7. Department of Rheumatology and Internal Diseases, Poznan University of Medical Science, Poznan, Poland.
  8. Department of Rheumatology and Internal Diseases, Poznan University of Medical Science, Poznan, Poland.
  9. Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznan, Poland.
  10. Eli Lilly and Company, Indianapolis, IN, USA.
  11. Department of Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland. paradowska_aga@interia.pl

CER14832
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PMID: 35084314 [PubMed]

Received: 26/05/2021
Accepted : 25/10/2021
In Press: 05/01/2022

Abstract

OBJECTIVES:
Systemic lupus erythematosus (SLE) is an autoimmune disease, and IL-1β, IL-10, and TNF-α genes are important in the pathogenesis of this disease. We studied the impact of IL-1β-511, IL-1β +3953, IL-10 -592, IL-10 -1082, TNF-α -308, TNF-α -238, and TNF-α +489 polymorphisms on SLE risk and phenotype in SLE patients and healthy controls.
METHODS:
We genotyped SLE patients and healthy controls by real-time PCR on QuantStudio 5 (Applied Biosystems) and measured levels of cytokines by enzyme-linked immunosorbent assay (ELISA).
RESULTS:
We indicated that TNF-α -308, IL-10 -592, IL-10 -1082, IL-1β-511 and IL-1β +3953 polymorphisms affect SLE risk. Furthermore, we exposed that some of the TNF-α +489, TNF-α -238, IL-10 -1082 and IL-1β +3953 genotypes are connected with the SLE phenotype. Moreover, we discovered the linking between specific genotypes and the serum concentrations of TNF-α, IL-1β, and IL-10.
CONCLUSIONS:
In conclusion, our study revealed that IL-1β-511, IL-1β +3953, IL-10 -592, IL-10 -1082, and TNF-α -308 polymorphisms may affect SLE risk and phenotype.

DOI: https://doi.org/10.55563/clinexprheumatol/qdgq0v

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