impact factor, citescore
logo
In press
In Press
Recent issue
Recent issue
Recent Supplement
Recent supplement
archives
Archives
articles free
Free to view
Search
Search
 

Paediatric Rheumatology

 

Evaluation of clinical outcomes in systemic juvenile idiopathic arthritis patients treated with biological agents in Turkey: the TURSIS study

1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19

 

  1. Paediatric Rheumatology, University of Health Sciences, Istanbul, Umraniye Training and Research Hospital, Istanbul, Turkey. drbetulsozeri@gmail.com
  2. Paediatric Rheumatology, University of Health Sciences, Istanbul, Umraniye Training and Research Hospital, Istanbul, Turkey.
  3. Paediatric Rheumatology, Istanbul University-Cerrahpasa, Istanbul, Turkey.
  4. Paediatric Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
  5. Paediatric Rheumatology, Erciyes University Faculty of Medicine, Kayseri, Turkey.
  6. Paediatric Rheumatology, Health Sciences University, Sami Ulus Training and Research Hospital, Ankara, Turkey.
  7. Paediatric Rheumatology, Health Sciences University, Dr Behcet Uz Children’s Hospital, Izmir, Turkey.
  8. Paediatric Rheumatology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey.
  9. Paediatric Rheumatology, Istanbul University, Faculty of Medicine, Istanbul, Turkey.
  10. Paediatric Rheumatology, Istanbul University-Cerrahpasa, Istanbul, Turkey.
  11. Paediatric Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
  12. Paediatric Rheumatology, Istanbul University-Cerrahpasa, Istanbul, Turkey.
  13. Paediatric Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
  14. Paediatric Rheumatology, Istanbul University-Cerrahpasa, Istanbul, Turkey.
  15. Paediatric Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
  16. Paediatric Rheumatology, Erciyes University Faculty of Medicine, Kayseri, Turkey.
  17. Paediatric Rheumatology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey.
  18. Paediatric Rheumatology, Istanbul University-Cerrahpasa, Istanbul, Turkey.
  19. Paediatric Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

CER16563
2024 Vol.42, N°1
PI 0194, PF 0201
Paediatric Rheumatology

Free to view
(click on article PDF icon to read the article)

PMID: 37497697 [PubMed]

Received: 03/02/2023
Accepted : 12/07/2023
In Press: 24/07/2023
Published: 24/01/2024

Abstract

OBJECTIVES:
Biological drugs are one of the most effective treatment methods for systemic juvenile idiopathic arthritis (SJIA) and can significantly prevent morbidity and mortality. This study aimed to evaluate the efficacy and safety of biologics in patients with SJIA and provide real-life data that might help improve the outcomes.
METHODS:
TURSIS was a retrospective multicentre study carried out in patients with SJIA for whom a biological treatment had been initiated between 1st March 2013 and 30th December 2018. Data include patients’ characteristics, laboratory-clinical results, outcomes, and safety-related variables. The 24-month follow-up data of the patients and the efficacy and safety of biological drugs were evaluated.
RESULTS:
147 patients were enrolled. The clinical course of the disease was as follows; it was monocyclic in 38.1%, polycyclic in 49%, and persistent in 12.9% of patients. First-choice biologics were interleukin (IL)-1 blockers in the majority of patients (56.5%), followed by the anti-IL-6 (25.2%) and anti-TNF-alpha drugs (18.4%). Anakinra was the most preferred biologic agent in patients with macrophage activation syndrome (MAS), and tocilizumab was used more frequently in patients with persistent type (p=0.000 and p=0.003). The most frequent switch rate was seen in patients receiving anakinra (n=40/68, 58.8%), and it was most frequently switched to canakinumab (n=32/40, 80%). Better physician’s global assessment scores were achieved in patients treated with anakinra in Month 3, compared to other treatments (p=0.04).
CONCLUSIONS:
The results of our study support the efficacy of biological drugs in particular anti-IL-1 and anti-IL-6 drugs, in the treatment of SJIA. These treatments resulted in improvement in activity of disease and provide a considerable decrease in the frequency of MAS.

DOI: https://doi.org/10.55563/clinexprheumatol/j611kr

Rheumatology Article

Rheumatology Addendum