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Nuts and bolts of salivary gland pathology in primary Sjögren’s syndrome

1, 2, 3, 4, 5, 6, 7, 8, 9

 

  1. Rheumatology Clinic, Department of Medicine, Azienda Sanitaria Universitaria Friuli Centrale c/o University of Udine, Italy. zabottialen@gmail.com
  2. Rheumatology Clinic, Department of Medicine, Azienda Sanitaria Universitaria Friuli Centrale c/o University of Udine, Italy.
  3. Rheumatology Clinic, Department of Medicine, Azienda Sanitaria Universitaria Friuli Centrale c/o University of Udine, Italy.
  4. Rheumatology Clinic, Department of Medicine, Azienda Sanitaria Universitaria Friuli Centrale c/o University of Udine, Italy.
  5. Rheumatology Clinic, Department of Medicine, Azienda Sanitaria Universitaria Friuli Centrale c/o University of Udine, Italy.
  6. Rheumatology Clinic, Department of Medicine, Azienda Sanitaria Universitaria Friuli Centrale c/o University of Udine, Italy.
  7. Institute of Anatomic Pathology, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy.
  8. Rheumatology Clinic, Department of Medicine, Azienda Sanitaria Universitaria Friuli Centrale c/o University of Udine, Italy.
  9. Institute of Anatomic Pathology, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy.

CER17155
2023 Vol.41, N°12
PI 2525, PF 2537
Reviews

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PMID: 38079343 [PubMed]

Received: 21/09/2023
Accepted : 23/10/2023
In Press: 29/11/2023
Published: 23/12/2023

Abstract

Primary Sjögren’s syndrome (pSS) is a chronic, systemic, inflammatory autoimmune disease characterised by lymphocyte proliferation and progressive damage to exocrine glands. Salivary gland histopathology based on salivary gland biopsy is relevant for the diagnosis of pSS and therefore broadly applied in clinical practice. Tissue can be obtained from labial salivary glands (LSG) biopsy or from major salivary glands (MSG) biopsy, namely the parotid; in this latter scenario, the procedure can be either an open surgical biopsy or a US guided core needle biopsy. In this review we will: i) present the histopathological findings that may be encountered by pathologists on biopsies from pSS patients; ii) discuss the advantages and disadvantages of the surgical and/or imaging guided procedures to obtain tissues from LSG or MSG; iii) describe the histopathological features of lymphoma of MSG in pSS patients.

DOI: https://doi.org/10.55563/clinexprheumatol/fcjoqx

Rheumatology Article