Prognostic factors for erosive rheumatoid arthritis

CER338
2010 Vol.28, N°1
PI 0114, PF 0123
Review

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PMID: 20346251 [PubMed]

Received: 13/04/2009
Accepted : 26/06/2009
In Press: 11/03/2010
Published: 15/03/2010

Abstract

ABSTRACT:The course of rheumatoid arthritis (RA) varies among patients, ranging from a mild disease with a small impact on patient`s functional capacity to a severe, erosive and catastrophic disease accompanied by subluxations, deformities and subsequent poor quality of life. In clinical practice, the prediction of the outcome of RA is substantial in terms of making the right therapeutic decision for each patient. Reliable prognostic factors of long-term outcome are needed, so as to distinguish patients prone to severe disease course from patients with a smaller probability of severe structural damage. For the former group early aggressive treatment is required, whereas in the latter group remission may be achieved with less aggressive and potentially less toxic treatments. In the present review, the predictive role of demographic, clinical, laboratory, imaging, immunological and genetic characteristics of RA patients is discussed.