Interactions of the innate and adaptive arms of the immune system in the pathogenesis of spondyloarthritis

CER3936
2011 Vol.29, N°2
PI 0322, PF 0330
Review

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PMID: 21269576 [PubMed]

Received: 17/06/2010
Accepted : 05/10/2010
In Press: 19/04/2011
Published: 19/04/2011

Abstract

The immune system can be divided into the innate and adaptive arms. Historically, most of the research into the pathogenesis of spondyloarthritis (SpA) and other types of chronic arthritis focused on the adaptive immune system. Recently, the pendulum has shifted, and much current work in SpA focuses on innate immunity. Herein, I summarise evidence demonstrating that both the innate and the adaptive arms of the immune system are involved in the pathogenesis of SpA, propose a mechanism in which both arms interact to maintain chronic arthritis, and discuss potential research directions.