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Tumour markers in rheumatoid arthritis-associated interstitial lung disease

1, 2, 3, 4, 5

 

  1. Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
  2. Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.
  3. Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
  4. Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China. liangzongan@163.com
  5. Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.

CER8817
2016 Vol.34, N°4
PI 0587, PF 0591
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PMID: 27213221 [PubMed]

Received: 28/07/2015
Accepted : 07/01/2016
In Press: 19/05/2016
Published: 14/07/2016

Abstract

OBJECTIVES:
Interstitial lung disease (ILD) is the most common pulmonary extra-articular manifestations of rheumatoid arthritis (RA), but the pathogenesis of RA-ILD is unknown. The purpose of this study was to investigate the tumour markers levels in patients of rheumatoid arthritis-associated interstitial lung disease (RA-ILD) and to explore the diagnostic value of serum tumour markers for RA-ILD.
METHODS:
Twenty-eight patients with RA-ILD and 83 patients with RA only were included. Serum levels of tumour markers carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 15-3, CA125, and CA19-9 were measured.
RESULTS:
Tumour markers CA15-3, CA125 and CA19-9 were increased in RA-ILD patients compared with RA without ILD patients. Logistic regression analysis revealed that older age (OR=1.06, 95% CI=[1.02-1.11]) and higher CA125 (OR=1.03, 95% CI=[1.01-1.05]) related to the increased risk of RA-ILD. ROC curve analysis showed the relationship between CA125 and RA-ILD was moderate (area under ROC curve (AUC)=0.78, 95% CI=[0.68-0.88]). In addition, CA125 levels above the normal reference (<35 U/ml) raised the risk of RA-ILD (OR=6.00, 95% CI=[2.37-15.16]).
CONCLUSIONS:
RA patient with older age and elevated tumour markers especially CA125 levels should be evaluated to check whether there is a potential of ILD.

Rheumatology Article