Special Lecture
Immunopathogenesis of inflammatory bowel diseases: functional role of T cells and T cell homing
S. Zundler1, M.F. Neurath2
- Department of Medicine 1, University of Erlangen-Nuremberg, Kussmaul Campus for Medical Research & Translational Research Center, Erlangen, Germany.
- Department of Medicine 1, University of Erlangen-Nuremberg, Kussmaul Campus for Medical Research & Translational Research Center, Erlangen, Germany. markus.neurath@uk-erlangen.de
CER8912
2015 Vol.33, N°4 ,Suppl.92
PI 0019, PF 0028
Special Lecture
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PMID: 26458165 [PubMed]
Received: 28/08/2015
Accepted : 01/09/2015
In Press: 12/10/2015
Published: 14/10/2015
Abstract
Inflammatory bowel diseases (IBD) are believed to arise from a complex interplay of environmental factors, genetic susceptibility, epithelial barrier defects and dysregulation of the intestinal immune system. Although the exact mechanisms of contribution and interference of these players are still not clear, significant advances have been achieved in understanding the immunopathogenesis of IBD in recent years resulting in novel and targeted therapeutic strategies. We will begin this review by giving a brief outline of current pathogenetic concepts of IBD and then focus on the description of the present knowledge of T cell function and regulation in the context of IBD. Moreover, we will summarise the progress on the emerging field of gut homing and delineate some implications for future therapeutic approaches.
